Blood flow resistance during hemodilution: effect of plasma composition

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Blood flow resistance during hemodilution: effect of plasma composition.

OBJECTIVES To investigate the causes of wide variations in reported effects of hemodilution on flow resistance of vascular beds. METHODS (a) In a meta-analysis of 28 prior studies, resistance values at hematocrits of zero (R0) and 0.45 (R0.45) were derived. Study design characteristics (presence of vasodilatory reserve or leukocytes, species, tissue, hemodiluent) were tested by ANOVA for thei...

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Effect of hemodilution on the distribution of renal blood flow.

We evaluated the effects of hemodilution, expansion of intravascular volume, and expansion of interstitial volume on the distribution of cortical renal blood flow, utilizing the microsphere technique. Hemodilution without volume expansion (saline exchange) produced an increase in fractional blood flow in zone 1 (outermost zone) of the cortex from 34 plus or minus 1% to 43 plus or minus 2% and a...

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Effect of hemodilution on regional cerebral blood flow.

Regional cerebral blood flow decreases during chronic hyperglycemia, a condition frequently associated with elevated hematocrit. To test the hypothesis that an elevated hematocrit is responsible for the reduced regional cerebral blood flow during chronic hyperglycemia, I used isovolemic hemodilution to normalize the hematocrit in seven normoglycemic and seven streptozotocin-treated (hyperglycem...

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Effect of Hemodilution on Regional Cerebral Blood Flow During Chronic Hyperglycemia in Rats

Regional cerebral blood flow decreases during chronic hyperglycemia, a condition frequently associated with elevated hematocrit. To test the hypothesis that an elevated hematocrit is responsible for the reduced regional cerebral blood flow during chronic hyperglycemia, I used isovolemic hemodilution to normalize the hematocrit in seven normoglycemic and seven streptozotocin-treated (hyperglycem...

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Effect of red blood cell rigidity on tumor blood flow: increase in viscous resistance during hyperglycemia.

Elevated glucose level and low pH have been shown to increase red blood cell (RBC) rigidity. This increased rigidity has been proposed as one factor which mediates the tumor blood flow (TBF) reduction during hyperglycemia by (a) causing RBC entrapment and hence increasing geometric resistance and (b) increasing viscous resistance to blood flow. However, due to the inability to measure these res...

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ژورنال

عنوان ژورنال: Cardiovascular Research

سال: 1998

ISSN: 0008-6363

DOI: 10.1016/s0008-6363(97)00226-5